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KMID : 0369820050350020101
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Jorunal of Korean Pharmaceutical Sciences
2005 Volume.35 No. 2 p.101 ~ p.106
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Effect of Naringin on the Pharmacokinetics of Nifedipine in Rabbits
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나종학/Na CH
최준식/Choi JS
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Abstract
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The pharmacokinetics of oral nifedipine (5 mg/kg) was studied in rabbits given after or simultaneously with naringin (1.5, 7.5 and 15 mg/kg, respectively). The area under the plasma concentration-time curve (AUC) and the peak concentration (C_(max)) of nifedipine coadrninistered or pretreated with naringin were significantly increased (p < 0.05, coad.; p < 0.01, pret.) compared with the control group. The absolute bioavailability (AB%) of nifedipine was significantly (p < 0.05, coad.; p < 0.01, pret.) higher by 22.3 - 28.1% compared to the control (17.9%). The relative bioavailability (RB%) of nifedipine was higher by 1.24 - 1.43 times (coad.) and 1.32 - 1.57 times (pret.) than those of the control, showing that preatreatment of naringin was more effective than that of the coadministration of naringin. Naringin did not show significant effect on the Tmax and t_(1/2) of nifedipine. It is suggested that naringin may alter pharmacokinetic paramiters of nifedipine by inhibition of P-glycoprotein efflux pump and its first-pass metabolism. The dosage of nifedipine should be adjusted when it is administered with naringin in a clinical situation.
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KEYWORD
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Nifedipine, Naringin, Pharmacokinetics, P-glycoprotein, First-pass metabolism
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